Endocrine Abstracts

A 29 year old lady with a background Hx of asthma came to the Ambulatory clinic with palpitations in the mid of Dec 2022. She was found to have an elevated heart rate of 120/min, regular and EKG showed Sinus Tachycardia. BP was Normal and weight was stable. She was also complaining of loose Bowls for the last few months. She denied any eye signs. She was a smoker and was not pregnant (She was not planning pregnancy in the near future). Her Bloods were Normal with stable U&...

Introduction: The focus on diabetic complications has increased over the years yet it is only recently that research has identified a link between ethnicity and the development of diabetic complications.Aims: To establish the relationship between ethnic group and the prevalence of either diabetic nephropathy or neuropathy.Method: A retrospective note review was undertaken for all diabetic patients who had a status of ‘current&...

With the ENETS guidelines update, there are a number of key issues tackled with this common subtype of NET. Terminology is clarified. Whether one uses neuroendocrine tumour, or neoplasm, as mentioned in the guidelines, the terms ‘midgut’ or ‘hindgut’ are thought not to be as helpful as indicating the primary anatomical site e.g. jejuno-ileal, rectal, colonic, caecal, appendiceal, etc.Grading with Ki-67 proliferation index, assessed fr...

Duodenal neuroendocrine neoplasms (d-NENs) account for approximately 2% of all NENs, frequently encountered incidentally at endoscopy. They can be classified in a number of ways: ampullary/peri-ampullary and non-ampullary; gastrinomas, somatostatinomas, non-functional d-NENs, duodenal gangliocytic paragangliomas and high-grade poorly differentiated NECs. More than 90% arise in the 2st or 2nd part of the duodenum. ENETS guidelines suggest managing d-NENs according to size, with...

We present an interesting case of a 50-year-old woman with previous history of alcohol dependence, depression & oesophagitis who was brought to the emergency department by ambulance with vomiting, back pain and feeling generally unwell. Her GCS was 14/15, HR128/min, RR 32/min, BP 111/60, temperature 35.2 & CBG 11.2mmol. She reported consuming one bottle of Vodka every day. Initial venous blood gas analysis showed severe metabolic acidosis (pH 6.79, HCO3 3, Lactate 15, ...

Introduction: Adrenocortical carcinomas (ACCs) are rare; incidence is approximately 1–2 per million population per year. These arefrequently aggressive tumours that may or may not be functional. The primary potentially curative treatment for ACC is surgery with currently mixed opinion among experts regardingadjuvant Mitotane treatment.The Case: 60 years old female was seen in clinic for work up of incidental adrenal mass. ...

Antithyroid drugs can cause hepatic dysfunction, from mild derangement to severe, fulminant failure. It is well known that propylthiouracil may cause fulminant liver failure yet we present an exceptionally rare case of this type of adverse drug reaction with carbimazole.A 75 year old woman presented to hospital with a fall and a two day history of jaundice. Six weeks earlier, she had been diagnosed with both congestive cardiac failure and G...

Introduction: Adrenocortical carcinomas (ACCs) are rare; incidence is approximately 1–2 per million population per year. These arefrequently aggressive tumours that may or may not be functional. The primary potentially curative treatment for ACC is surgery with currently mixed opinion among experts regardingadjuvant Mitotane treatment.The Case: 60 years old female was seen in clinic for work up of incidental adrenal mass. ...

Antithyroid drugs can cause hepatic dysfunction, from mild derangement to severe, fulminant failure. It is well known that propylthiouracil may cause fulminant liver failure yet we present an exceptionally rare case of this type of adverse drug reaction with carbimazole.A 75 year old woman presented to hospital with a fall and a two day history of jaundice. Six weeks earlier, she had been diagnosed with both congestive cardiac failure and G...

Introduction: Amiodarone, a drug with high iodine content, is commonly associated with thyroid dysfunction. There are two well-recognized forms of amiodarone induced thyrotoxicosis. Thyrotoxicosis due to iodine excess leading to increased thyroid hormone synthesis is referred to as Amiodarone induced thyrotoxicosis type 1 (AIT type 1) whilst thyrotoxicosis due to direct toxic effect (thyroiditis) is known is amiodarone induced thyrotoxicosis Type 2 (AIT type 2). The aim in bot...